Phytother Res. Effect of red clover isoflavones over skin, appendages, and mucosal status in postmenopausal women. Obstet Gynecol Int. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation. Arch Toxicol. By signing up, you are consenting to our privacy policy. You can opt out at any time. Thank you for joining us. We've sent you an email confirmation, which also contains your welcome offer. More from the Knowledge Centre.
Family Health LactoLycopene, lycopene and fertility In this article we look at the potential benefits of a compound called lycopene for sperm quality, and explain how you can get enough to make a difference Health Conditions What is the menopause?
Causes, symptoms, and treatments The menopause is a normal and natural part of a woman's life-cycle. We look at signs that it has begun, common symptoms, and a range of steps you can take to increase the chances of a comfortable menopause.
Ingredients and Nutrition Sage: health benefits of Salvia officinalis during the menopause Sage has been used for centuries for treating illness in various forms, but now we are also seeing its effect on easing menopause symptoms. Enjoy an exclusive offer when you sign up Sign up for email updates and we'll send you the first of our exclusive deals and discounts straight to your inbox.
See you in your inbox! In postmenopausal women, supplementation alleviated vasomotor and menopausal symptoms 18 A meta-analysis of a standardized extract suggests potential reductions in total cholesterol in peri- and postmenopausal women, but studies were heterogeneous Isoflavones may also improve bone loss In a trial involving osteopenic postmenopausal women, a red clover extract rich in isoflavones, aglycones, and probiotics attenuated bone mineral density loss caused by estrogen deficiency and improved bone turnover Dietary isoflavone intake also improved arterial compliance, an index of large artery elasticity which is an important cardiovascular risk factor Of concern are findings that red clover inhibits the growth of normal prostate cells and increases resistance of prostate cancer cells to high-dose radiation in vitro Patients should consult with their physicians before taking red clover supplements.
Formononetin, an isoflavone, induced apoptosis in human breast cancer cells by activating the Ras-p38 mitogen-activated protein kinase in ER-positive breast cancer cells It also inhibited proliferation of human osteosarcoma U2SO cells by decreasing expression of miR and Bcl-2, an apoptotic repressor, while increasing Bax, a pro-apoptotic protein The isoflavone Biochanin A inhibited activity and gene expression of aromatase, an enzyme that catalyzes the conversion of androgen to estrogen 2.
In addition, it protected dopaminergic neurons against lipopolysaccharide-induced damage by inhibiting microglial activation and proinflammatory factors 3. An isoflavone-enriched fraction showed neuroprotective activity in human cortical neurons as well, possibly due to antioxidant and estrogenic effects 4.
In a murine model, red clover isoflavones reduced skin aging induced by estrogen deprivation following ovariectomy 5. Subdural hematoma: In a year-old woman with no other risk factors for bleeding except long-term use of red clover supplements for postmenopausal symptoms. After postoperative re-hemorrhage, an intraoperative thromboelastogram confirmed that antiplatelet effects were more likely than coumarin toxicity.
There was no further bleeding after the patient was subsequently treated with tranexamic acid and platelet transfusions 6. Subarachnoid hemorrhage: In a year-old woman following use of an herbal supplement containing red clover, dong quai , and Siberian ginseng for perimenopausal hot flashes.
Symptoms resolved after supplement discontinuation Clinical relevance has yet to be determined. Methotrexate: Red clover was reported to cause toxicity, resulting in severe vomiting and epigastric pain, when used along with methotrexate injections Red Clover. Developing Your Personal Care Plan. Integrative Medicine at Home Membership Program. About Mind-Body Therapies. How It Works. Purported Uses. To relieve menopause symptoms Studies on whether red clover may help reduce menopausal symptoms are mixed, and additional study is needed to confirm any positive effects as well as safety with long-term use.
To prevent heart disease in postmenopausal women A few clinical trials have looked at the effects of red clover on development of risk factors for heart disease in postmenopausal women, with no strong evidence that it helps. Most studies found that red clover had no effect on blood cholesterol or triglyceride levels. One clinical trial found that red clover increased the elasticity of major arteries, which may help prevent a gradual rise in blood pressure that can contribute to heart disease.
Do Not Take If. You have a hormone-sensitive disease such as estrogen receptor-positive breast cancer, ovarian cancer, endometriosis : Red clover may have estrogenic activity and should be avoided or used cautiously by patients with estrogen-sensitive disease. You are taking methotrexate: A case report suggests red clover may cause toxic effects, including severe vomiting and pain in the upper abdomen. You are taking warfarin or other blood thinners: Preclinical studies suggest red clover can increase the risk of bleeding.
Side Effects. Philadelphia, PA: Lippincott; The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Effects of red clover extracts on breast cancer cell migration and invasion.
Gynecol endocrinol. Botanical Safety Handbook. Mueller M, Jungbauer A. Red clover extract: a putative source for simultaneous treatment of menopausal disorders and the metabolic syndrome. Nachtigall LE. Isoflavones in the management of menopause.
Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab. The role of isoflavones in menopausal health: consensus opinion of the North American Menopause Society.
Effects of phytoestrogenic isoflavones from red clover Trifolium pratense L. Phytother Res. Panay N. Taking an integrated approach: managing women with phytoestrogens. Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer. Menopause Int. Stephens FO. Phytoestrogens and prostate cancer: possible preventive role. Indian J Pharm Sci. Umland EM. Treatment strategies for reducing the burden of menopause-associated vasomotor symptoms.
J Manag Care Pharm. Isoflavones and breast cancer. Plant extracts for the treatment of menopausal women: Safe? Epub Aug 8. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. Red clover capsules and tablets seem to be the most common way to take this herbal supplement.
The benefits include:. People have been enjoying red clover tea for hundreds of years, and now you can get yours in a handy teabag. Red clover tea benefits include:. B vitamins, magnesium, green tea extract, calcium and soya isoflavones are popular examples. Handpicked content: 11 of the best natural menopause remedies.
Advice is for information only and should not replace medical care. Please check with your GP before trying any remedies. Consumers, particularly those with allergies or intolerances, should read all product labeling, warnings, and directions prior to use or consumption. Children should not take any licensed herbal medicinal products. Your Cookie Settings This site uses cookies and similar technologies for performance, social media and advertising purposes in order to provide a customised user experience and understand how our sites are used.
Red clover: overview, benefits, dosage, side effects. What is red clover and what does it do? May relieve hot flushes and night sweats As red clover is high in isoflavones, it is believed to help decrease the frequency and severity of some menopause symptoms, like night sweats and hot flushes.
They found that red clover isoflavones can: 12 Increase bone density Slow down the rate at which calcium is removed from bone tissue for absorption into the blood Speed up the production of new bone However, even though the results appear positive, more research is necessary. May contribute to heart health Some research suggests that red clover may help improve the heart health of postmenopausal women.
However, even though the results appear positive, more research is necessary.
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