Why cushings syndrome and obesity

Cloutier, M. Copinschi, G. Acta endocr. Cushing, H. Johns Hopk. Dahms, W. Dhom, G. Berlin-Heidelberg-New York: Springer Eberlein, W. Philadelphia-London: Saunders Fontanellaz, H. Acta 26 , 28 Gilbert, M. Pediatrics 46 , Girard, J. Hayles, A. Pediatrics 37 , 19 Hellmann, L. Killinger, D. Klevit, H. Krieger, D. Lie, S. Liddle, G. Endocrinology 57 , Loridan, L. Masuda, M. Mattingly, D. McArthur, R. Mayo Clin. Neville, A.

In our study population, which includes morbidly obese patients in major proportion, mean age of the patients was young and also the prevalence of glucose intolerance and hypertension was high. The reported prevalence of CS among the obese patients varies widely between the different studies, ranging from 0. In the other three studies, CS was screened in a small number of patients [ 10 , 11 , 14 ]. Tiryakioglu et al. Some studies evaluated the prevalence of occult CS in overweight and obese patients with uncontrolled diabetes and it was found to be 0—9.

In our study, this ratio was 1. We suggest that examination for hypercortisolism should only be performed in obese patients with a cushingoid appearance and hypertension or glucose intolerance or dyslipidaemia. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article of the Year Award: Outstanding research contributions of , as selected by our Chief Editors. Read the winning articles. Academic Editor: C. Received 07 May Accepted 02 Jun Published 11 Jun Abstract Background. Results consecutive obese patients were screened for CS. BMI: body mass index. Table 1. Table 2. References J. Etxabe and J. View at: Google Scholar A.

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Omura, J. Saito, K. Lynn D. Traditionally, exams of patients with glucocorticoid excess focused on the presence of changes in anabolism the chemical synthesis of molecules. However, analyses of anti-anabolic changes of cortisol — including osteopenia lower bone density , thin skin, and ecchymoses injury that causes subcutaneous bleeding — are an effective way to make this distinction.

The test, which should be done with the most stringent techniques available, averages the augmented secretion of cortisol in the morning and the diminished secretion in the afternoon and at night.

Patients with obesity and depression should not show decreased plasma cortisol levels when dexamethasone is suppressed. This may be due to glucocorticoids being administered to the patient. In this case, the glucocorticoid must be identified and discontinued.